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Design, synthesis, biological evaluation and molecular docking study of novel urea-based benzamide derivatives as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY · IF 7.09 · 2022 · DOI: 10.1016/j.ejmech.2022.114790
关联产品: Cell Cycle and Apoptosis Analysis Kit 细胞周期与细胞凋亡检测试剂盒

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY · IF 7.09 · 2022 · DOI: 10.1016/j.ejmech.2022.114194
关联产品: MitoSOX Red Mitochondrial Superoxide Indicator 线粒体超氧化物红色荧光探针;Mitochondrial Permeability Transition Pore Assay Kit ( flow cytometry) 线粒体膜通透性转换孔检测试剂盒(流式分析)

pH-programmed responsive nanoplatform for synergistic cancer therapy based on single atom catalysts

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY · IF 7.09 · 2022 · DOI: 10.1016/j.ejmech.2022.114236
关联产品: Annexin V-EGFP/PI Apoptosis Detection Kit Annexin V-EGFP/PI 细胞凋亡检测试剂盒;Annexin V-FITC/PI Apoptosis Detection Kit Annexin V-FITC/PI 细胞凋亡检测试剂盒

Discovery of novel VEGFR-2-PROTAC degraders based on the localization of lysine residues via recruiting VHL for the treatment of gastric cancer

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY · IF 7.09 · 2022 · DOI: 10.1016/j.ejmech.2022.114821
关联产品: Enhanced ECL Chemiluminescent Substrate Kit 增强型ECL化学发光检测试剂盒;Annexin V-FITC/PI Apoptosis Detection Kit Annexin V-FITC/PI 细胞凋亡检测试剂盒;2× Ultima Amplification Mix/ 高保真DNA扩增模块(转座酶适用) …

Novel protein kinase inhibitor TT-00420 inhibits gallbladder cancer by inhibiting JNK/JUN-mediated signaling pathway

CELLULAR ONCOLOGY · IF 7.05 · 2022 · DOI: 10.1007/s13402-022-00692-7
关联产品: InStab™ Phosphatase Inhibitor Cocktail (100×, Stock Solution) 磷酸酶抑制剂混合物(100×,储存液);Cell Counting Kit (CCK-8) CCK-8试剂盒;InStab™ Protease Cocktail, EDTA-free, 100× DMSO Stock Solution 蛋白酶抑制剂Cocktail,EDTA-free,100× DMSO储液 …

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