Fetal bovine serum quality identification method: procurement acceptance and defect map analysis

I. First check the source of documents and compliance

The first step in identifying fetal bovine serum quality is often outside the laboratory.The supplier qualification, certificate of origin, quarantine certificate and quality inspection report shall be verified at the time of procurement.Regular channels usually provide complete shipping documents, including collection area, filter specifications, sterility and mycoplasma detection information.Judgment cannot be based solely on price or promotional language.

Pay attention to whether the serum comes from legally traceable raw materials and whether the information in the file is consistent with the physical label.If the label is blurred, the batch number is missing, or the report does not match the incoming batch, it should be suspended and a quality review should be initiated.

II. Cold Chain Transportation and Storage Temperature Verification

Serum is sensitive to temperature during transport and storage.It is generally recommended to store at -20°C or lower to avoid repeated freezing and thawing.Cold chain temperature records should be checked upon arrival for prolonged ambient temperature exposure or temperature fluctuations.If the ice pack in the package has completely melted, the serum has thawed and the temperature is high, the stability of the active ingredient may be affected.

Record the thermometer or temperature recorder data in the box at the time of receipt

Check if the shipping time is within the supplier's commitment

Confirm that the warehouse temperature monitoring and alarm device is normal

III. Rapid Identification of Appearance Defects

Appearance anomalies visible after thawing are common clues to quality defects.Normal fetal bovine serum is generally clear, yellowish in color, and allows a small amount of fibrin to precipitate.Beware of hemolysis, microbial contamination or protein denaturation in case of large amounts of flocculation, jelly-like, muddy, reddish or dark colors